Fermentation: Precise Gas Control for Reproducible Processes

Thanks to Bürkert mass flow controllers, reproducible fermentation processes enable precise, automated gas control.

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Definition of Fermentation

In biotechnology, fermentation refers to the conversion of biological materials. It requires the help of biocatalysts such as enzymes or cells and depends on optimum temperature conditions (usually 35 °C to 37 °C).

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What plays the important roles in fermentation?

An optimised fermentation requires precise control of all parameters. The type and concentration of the nutrients, the temperature, oxygen content and pH value are critical. Reproducible processes are fundamental to consistently high product quality. The challenges inherent in this include in particular:

  • Optimising the gas supply control.
  • Having all components comply with applicable approvals.
  • Ensuring that process data is documented and analysable.

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Reproducible Processes are Key

Fermentation processes involving microorganisms – such as bacteria or mammalian cells – play a key role these days in the production of medicines, chemicals, amino acids and much more.

Fermentation Process Reproducible Processes are Key - Burkert Thailand Distributor - Flu-Tech Co., Ltd. - @flutech.co.th
กระบวนการหมัก - What plays the important roles in fermentation - Burkert Thailand - Flu-Tech Co., Ltd. - @flutech.co.th

Processes that can be traced at any time help keep everything under control. This is the only way to produce consistent quality. Bürkert mass flow controllers (MFCs) help you do this.

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Mass flow Controller: Precise and Repeatable Gas Control

Be it research laboratory or pilot plant: Burkert mass flow controllers (MFCs) make the fermentation process reproducible. Since setting of the flow rate can be automated with repeat accuracy. Using just one device, you can control standard fermenter gases such as air, oxygen, nitrogen and carbon dioxide according to the needs of your cultures.

Advantages of Bürkert MFCs:

  1. Fermenter Gases: Calibrate up to four different gases
  2. Approval: Compliant with USP Class VI, FDA and available with 3.1 certificate
  3. No Fermentation Contamination: Parts that come into contact with media are made of stainless steel
  4. Wide Setting Range: Precise control of ultra-small to large gas quantities thanks to direct- measuring sensors

In contrast to measurements with floats and needle valves, MFCs guarantee identical processes. You also benefit from all the advantages of digitalisation, such as data that can be retrieved at any time.

Added Values for Your Process

What is the benefit of precise gas control for your fermentation processes? This is illustrated by the following points:

Flexible Integration of MFC Solutions

Ethernet, system bus or analogue interface? No matter which communication standard you use, the versatile MFC solutions fit your existing interfaces. We present three integration options below:

Bürkert Ethernet concept - Burkert Thailand Distributor Flu-Tech Co., Ltd. - @flutech.co.th
Ethernet concept

MFCs are connected directly to the higher visualization level via integrated industrial Ethernet switches.

Bürkert system bus concept - Burkert Thailand Distributor Flu-Tech Co., Ltd. - @flutech.co.th
Bürkert System Bus Concept

MFCs are connected to the Bürkert fieldbus gateway via CANopen-based büS interfaces.

  • Suitable for applications with numerous gas flow control loops.
  • Easy start-up: Preconfigured MFC systems are connected to the PLC via a gateway.
  • Permanent access to the device status thanks to digital communication.
Bürkert Standard signal concept - Burkert Thailand Distributor Flu-Tech Co., Ltd. - @flutech.co.th
Standard Signal Concept

MFCs are connected to the existing I/O system via analogue interfaces.

  • Connect MFCs via analogue standard signals and continue to use the existing automation concept.
  • You simply adapt the concept to the number of MFCs required.
MFCs and Available Interfaces:

Industrial Ethernet: PROFINET, EtherNet/IP, EtherCAT, Modbus TCP
Fieldbus: CANopen, RS485/ Modbus as well as PROFIBUS-DP via a gateway
Standard signals: 0/4 … 20 mA, 0 … 5/10 V (switchable)

One System Solution, Many Advantages

Burkert also offers modular, customised gas mixing units. We configure these units according to your requirements – using space-saving mass flow controllers arranged side by side, including valves. You receive the units already pre-tested for tightness, pressure and correct electrical operation. The advantages of a complete solution:

✓ You save installation costs
✓ You simplify your engineering tasks
✓ You do not need to order, store and assemble individual parts

Do you want to increase the efficiency of your plant and measure the flow profitably? Simply contact us for more information.

Type 8741 - Mass flow controller (MFC)mass flow meter (MFM) for gases - Burkert Thailand Fluid Control System Authorized Distributor Flu-Tech Co., Ltd. - @flutech.co.th

Reference: Burkert Thailand

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